Hacker News

https://download.ssrn.com/2026/1/6/5877662.pdf?response-cont...

How it works: - Client runs a local SOCKS5 proxy (127.0.0.1:1080) - Traffic is sent to server disguised as SMTP (EHLO, STARTTLS, AUTH) - DPI sees legitimate email session, not a VPN/proxy

Features: - One-liner install on any Linux VPS - Multi-user with per-user secrets and IP whitelists - Auto-generated client packages (just double-click to run) - Auto-reconnect on connection loss - Works with any app that supports SOCKS5

Tech: Python/asyncio, TLS 1.2+, HMAC-SHA256 auth

GitHub: https://github.com/x011/smtp-tunnel-proxy

https://www.wsj.com/tech/ai/ai-hackers-are-coming-dangerousl..., https://archive.ph/L4gh3

Great for parties where you rather be home tinkering.

https://www.tamarind.bio). Tamarind is an inference provider for AI drug discovery, serving models like AlphaFold. Biopharma companies use our library of leading open-source models to design new medicines computationally.

Here’s a demo: https://youtu.be/luoMApPeglo

Two years ago, I was hired at a Stanford lab to run models for my labmates. Some post-doc would ask me to run a set of 1-5 models in sequence with tens of thousands inputs and I would email them back the result after setting up the workflow in the university cluster.

At some point, it became unreasonable that all of an organization's computational biology work would go through an undergrad, so we built Tamarind as a single place for all molecular AI tools, usable at massive scale with no technical background needed. Today, we are used by much of the top 20 pharma, dozens of biotechs and tens of thousands of scientists.

When we started getting adoption in the big pharma companies, we found that this problem also persisted. I know directors of data science, where half their job could be described as running scripts for other people.

Lots of companies have also deprecated their internally built solution to switch over, dealing with GPU infra and onboarding docker containers not being a very exciting problem when the company you work for is trying to cure cancer.

Unlike non-specialized inference providers, we build both a programmatic interface for developers along with a scientist-friendly web app, since most of our users are non-technical. Some of them used to extract proteins from animal blood before replacing that process with using AI to generate proteins on Tamarind.

Besides grinding out images for each of the models we serve, we’ve designed a standardized schema to be able to share each model’s data format. We’ve built a custom scheduler and queue optimized for horizontal scaling (each inference call takes minutes to hours, and runs on one GPU at a time), while splitting jobs across CPUs and GPUs for optimal timing.

As we've grown to handle a substantial portion of the biopharma R&D AI demand on behalf of our customers, we've expanded beyond just offering a library of open source protocols.

A common use case we saw from early on was the need to connect multiple models together into pipelines, and having reproducible, consistent protocols to replace physical experiments. Once we became the place to build internal tools for computational science, our users started asking if they could onboard their own models to the platform.

From there, we now support fine-tuning, building UIs for arbitrary docker containers, connecting to wet lab data sources and more!

Reach out to me at deniz[at]tamarind.bio if you’re interested in our work, we are hiring! Check out our product at https://app.tamarind.bio and let us know if you have any feedback to support how the biotech industry uses AI today.

VaultSandbox is my attempt at fixing that. It's a self-hosted SMTP gateway (AGPLv3) that validates SPF, DKIM, DMARC, and rDNS on every incoming message. You keep your production email provider (Postmark, SendGrid, SES) in tests and you just change the recipient domain. No mocking, no config changes. There are client SDKs (Node, Python, Go, Java, .NET), plus a Web UI and a CLI for manual testing.

Some technical details:

Deterministic Tests Instead of polling or sleep loops, the SDKs use Server-Sent Events (SSE) so test assertions trigger the moment the mail hits the gateway.

Minimal infrastructure footprint Built with NestJS and Angular, with no external database dependency to keep the container footprint small and easier to reason about.

Post-Quantum Encryption I use ML-KEM-768 for the encryption layer. Incoming mail is encrypted immediately using a client-generated public key and the plaintext is discarded. The server only ever stores encrypted message data and cannot decrypt it. I chose PQ because I wanted to build something I wouldn't have to revisit in five years. If it handles large PQ keys reliably, everything else is easy.

Quick start: https://vaultsandbox.dev/getting-started/quickstart/

Site: https://vaultsandbox.com

I'd love feedback, especially on whether AGPLv3 would be a blocker for something you'd self-host in dev.

I created a small webapp, to create simple audio loops online. A bit rough around the edges but gets you started in less than 10 seconds on creating loops.