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Reflections on Americans' Net Worth

2026-09-02 @ 23:57:07Points: 31Comments: 46

METR Report on OpenAI / Hugging Face Hacking Incident

2026-09-02 @ 23:08:47Points: 101Comments: 84

Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

2026-09-02 @ 22:36:04Points: 41Comments: 53

I’m Lloyd, one of two founders of RonanRx (https://ronanrx.com/). We are building a vertically integrated pharmaceutical company with software for prescribing, telehealth, compounding, manufacturing, and delivery. We are starting with GLP-1s and peptides.

The path to RonanRx is fairly unconventional. During the pandemic, I built one of the largest mask manufacturing factories in the US. We could make a million masks in a day. We converted raw polypropylene pellets into finished pallets of masks.

I had a background in software from my YC W10 company, so we took a software approach to building our factory. We used machine learning and computer vision to optimize production. We also vertically integrated almost everything. It worked. We built an efficient manufacturing operation and grew the business to 50 million dollars in revenue. Then people actually stopped caring about masks. Fair enough.

Around the same time, I decided to try and lose the weight I had gained while building the factory. I ate nothing but chicken for six months. While this diet got some results, I plateaued. My doctor suggested tirzepatide, a GLP-1 medication.

For me, losing weight was only the beginning. "Food noise" was gone. I showed less interest in other compulsive behavior. I stopped scrolling Instagram and quit biting my nails. But that was just the beginning. I was born with a congenital heart defect called aortic stenosis. My whole life doctors told me I'd need open heart surgery in my 40s (I am 45 now). After just 18 months using tirzepatide, my cardiologist’s began to think (and still thinks) my surgery could be pushed back until I am 70 or 80.

This was all happening when I was deciding what to work on next. I wanted to keep working on manufacturing. I didn't want to build another product that could be replicated by a frontier model. Pharmaceutical manufacturing was the best combination of digital, physical, biological, and regulatory infrastructure I could find. The thing that bothered me was how disconnected all of the pieces were: telehealth, EHR, prescriptions, dispensing software, production, shipping. No one company has it all.

GLP-1s come in a handful of predefined doses, but patients obviously aren't standardized: they respond differently, lose weight at different rates, experience different side effects, and may need very different doses. Compounding pharmacies can fill customized prescriptions, but they are not built like software companies. Workflows are manual, fragmented, and disconnected from the patient’s data. It's our goal to connect those pieces with RonanRx.

Patients either come to us directly or are referred by a physician. Once a patient is in our system, we collect medical records, current meds, labs, and data from wearables. Our software follows the prescription through drug formulation, compounding, quality testing, and drug dispensing and distribution.

The most interesting feature is the feedback loop. As the patient is undergoing treatment, their response becomes data that can be used by their doctor to modify the treatment. We keep the doctor in the feedback loop.

We make money by selling drugs we manufacture. Because people can buy directly from us, their price is usually 3x-10x more affordable. We can do this because we start at the molecule and own the entire stack from manufacturing through prescribing, dispensing, and delivery, instead of paying a chain of middlemen at every step.

We are beginning with GLP-1s and peptides since this was where I personally experienced the issue; however, we are more interested in the potential of patient-specific pharmaceutical manufacturing.

We would love your feedback, especially if you have built pharmacy, manufacturing, clinical infrastructure, EHRs, or any other regulated software. There are a lot of assumptions in this model that should be tested.

Reasons robotics is hard

2026-09-02 @ 22:02:30Points: 67Comments: 28

Uber shuts operations in Nigeria and Uganda with immediate effect

2026-09-02 @ 21:46:33Points: 114Comments: 88

Nango (YC W23) is hiring across eng, product and GTM (SF and remote)

2026-09-02 @ 21:00:04Points: 1

Altair Basic Interpreter Source Code (1975) [pdf]

2026-09-02 @ 20:08:22Points: 48Comments: 32

I wanna live an NPC life

2026-09-02 @ 19:52:53Points: 227Comments: 200

Fable 5.1 World Modeling

2026-09-02 @ 19:49:01Points: 178Comments: 56

Muse Spark 1.3

2026-09-02 @ 19:35:04Points: 471Comments: 315

Qantas Airbus A380 engine failure in 2010 (2023)

2026-09-02 @ 18:42:41Points: 103Comments: 60

Embedded Rust RTOS vs. C RTOS

2026-09-02 @ 18:32:24Points: 71Comments: 37

Gemini 3.8 Flash and 3.8 Flash Cyber

2026-09-02 @ 15:12:40Points: 915Comments: 525

Google avoids a breakup of its ad tech business

2026-09-02 @ 14:46:16Points: 320Comments: 236

Exit the Cave

2026-09-02 @ 14:16:45Points: 231Comments: 83

WebLLM: high-performance in-browser LLM inference engine

2026-09-02 @ 14:02:35Points: 99Comments: 17

Three sites made 215,128 “best software” pages for AI. Perplexity cites them

2026-09-02 @ 13:59:59Points: 351Comments: 163

Poisson Disk Sampling

2026-09-02 @ 13:47:49Points: 140Comments: 19

Biggest dark matter detector spots a single weird particle

2026-09-02 @ 13:40:29Points: 269Comments: 89

Aging brains blend memories together instead of just forgetting them

2026-09-02 @ 12:59:09Points: 238Comments: 112

Can I opt out of my input or output data being used for training?

2026-09-02 @ 12:30:39Points: 403Comments: 170

Whistleblower warns Postal Service mail ballot system has catastrophic problems

2026-09-01 @ 16:41:13Points: 205Comments: 137

We could save petabytes of cache storage with Zstandard and Pingora

2026-09-01 @ 13:41:11Points: 87Comments: 33

Engineering of the fastest WebAssembly interpreters

2026-09-01 @ 12:25:13Points: 65Comments: 4

Wendell Berry has died

2026-09-01 @ 01:49:58Points: 162Comments: 87

A Selection of Los Alamos Rolodex Business Cards

2026-08-31 @ 19:25:44Points: 150Comments: 37

Reverse Engineering Unknown File Formats with ImHex

2026-08-31 @ 12:01:05Points: 145Comments: 31

Holden's Lightning Flight

2026-08-31 @ 11:29:44Points: 101Comments: 17

Product Backlog Problems: Why Your Hierarchy Is Broken

2026-08-31 @ 09:56:23Points: 23Comments: 17

Making the Internet Boring

2026-08-30 @ 20:20:30Points: 95Comments: 48

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